(2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

Base Information

Chemical Name:(2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol
CAS No.:126459-40-3
Molecular Formula:C₂₈H₂₉NO₂
Molecular Weight:411.544
Hs Code.:

Synonyms:(2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

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Chemical Property of (2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

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Technology Process of (2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

There total 2 articles about (2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 126459-37-8
(4S,1'S,2'S)-2-oxo-3-(9-phenylfluoren-9-yl)-4-(1'-hydroxy-2'-methyl-4'-hexynyl)oxazolidine

: 126459-40-3
(2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

Guidance literature:: With potassium hydroxide; In ethanol; for 18h; Heating;
DOI:10.1021/jo00298a025

Reference yield: 35.0%

: 126459-60-7
(4S,2'S)-2-oxo-3-(9-phenylfluoren-9-yl)-4-(1'-oxo-2'-methyl-4'-hexynyl)oxazolidine

: 126459-40-3
(2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

: 126459-39-0
(2S)-2-(N-methyl-N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octyn-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; a) -78 deg C, 30 min, 2) 30 deg C, 2h, c) 40-45 deg C, 50 min;
DOI:10.1021/jo00298a025

Reference yield:

: 126459-40-3
(2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

: 126576-07-6
(2S,3R,4R,6Z)-2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxy-4-methyl-6-octenoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1) TsOH / 2) SiO₂ / 1) THF, 24h

3: 94 percent / NaClO₂, NaH₂PO₄ / acetonitrile; 2-methyl-propan-2-ol; various solvent(s) / 0.08 h / 0 °C

4: 96 percent / NaCNBH₃, CF₃COOH / tetrahydrofuran / 0.33 h / 0 °C

5: 68 percent / H₂ / Lindlar's catalyst / methanol / 24 h

With sodium chlorite; sodium dihydrogenphosphate; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; trifluoroacetic acid; Lindlar's catalyst; silica gel; In tetrahydrofuran; methanol; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo00298a025