[(4R,5R)-5-((R)-1-Methyl-pent-3-ynyl)-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-methanol

Base Information

Chemical Name:[(4R,5R)-5-((R)-1-Methyl-pent-3-ynyl)-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-methanol
CAS No.:126501-62-0
Molecular Formula:C₂₉H₂₉NO₂
Molecular Weight:423.555
Hs Code.:

Synonyms:[(4R,5R)-5-((R)-1-Methyl-pent-3-ynyl)-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-methanol

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Chemical Property of [(4R,5R)-5-((R)-1-Methyl-pent-3-ynyl)-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-methanol

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Technology Process of [(4R,5R)-5-((R)-1-Methyl-pent-3-ynyl)-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-methanol

There total 4 articles about [(4R,5R)-5-((R)-1-Methyl-pent-3-ynyl)-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126459-37-8
(4S,1'S,2'S)-2-oxo-3-(9-phenylfluoren-9-yl)-4-(1'-hydroxy-2'-methyl-4'-hexynyl)oxazolidine

: 126501-62-0
(4S,5S,1'S)-3-(9-phenylfluoren-9-yl)-4-(hydroxymethyl)-5-(1'-methyl-3'-pentynyl)oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / KOH / ethanol / 18 h / Heating

2: 1) TsOH / 2) SiO₂ / 1) THF, 24h

With potassium hydroxide; toluene-4-sulfonic acid; silica gel; In ethanol;
DOI:10.1021/jo00298a025

Reference yield:

: 126459-60-7
(4S,2'S)-2-oxo-3-(9-phenylfluoren-9-yl)-4-(1'-oxo-2'-methyl-4'-hexynyl)oxazolidine

: 126501-62-0
(4S,5S,1'S)-3-(9-phenylfluoren-9-yl)-4-(hydroxymethyl)-5-(1'-methyl-3'-pentynyl)oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 34 percent / LiAlH₄ / tetrahydrofuran / a) -78 deg C, 30 min, 2) 30 deg C, 2h, c) 40-45 deg C, 50 min

2: 1) TsOH / 2) SiO₂ / 1) THF, 24h

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; silica gel; In tetrahydrofuran;
DOI:10.1021/jo00298a025

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 126459-40-3
(2S,3S,4S)-2-(N-(9-phenylfluoren-9-yl)amino)-3-hydroxy-4-methyl-6-octynol

: 126459-48-1
(1S,2S)-2-Methyl-1-[(S)-3-(9-phenyl-9H-fluoren-9-yl)-oxazolidin-4-yl]-hex-4-yn-1-ol

: 126501-62-0
(4S,5S,1'S)-3-(9-phenylfluoren-9-yl)-4-(hydroxymethyl)-5-(1'-methyl-3'-pentynyl)oxazolidine

Guidance literature:: With toluene-4-sulfonic acid; silica gel; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, 24h;
DOI:10.1021/jo00298a025