2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide

Base Information

• Chemical Name: 2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide
• CAS No.: 1332717-20-0
• Molecular Formula: C₁₆H₁₅Cl₂N₃O₃
• Molecular Weight: 368.219
• Mol file: 1332717-20-0.mol

Synonyms:2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide

Chemical Property of 2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide

There total 1 articles about 2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aceclofenac (89796-99-6) → 2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide (1332717-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

With hydrazine hydrate; sulfuric acid; In ethanol;

DOI:10.1007/s00044-010-9494-z

Reference yield: 81.0%

2,3,4,4a-tetrahydro-1H-xanthen-1-one (544693-22-3) + 2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide (1332717-20-0) → (E)-2-oxo-2-(2-(2,3,4,4a-tetrahydro-1H-xanthen-1-ylidene)hydrazinyl)ethyl-2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate

Guidance literature:

With acetic acid; In ethanol; for 8h; Reflux;

DOI:10.1016/j.bioorg.2018.11.053

Reference yield:

2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide (1332717-20-0) → [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate (1262801-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 12 h / Reflux

2.1: sodium ethanolate / ethanol / 4 h / Reflux

2.2: Reflux

With sodium ethanolate; potassium hydroxide; In methanol; ethanol;

DOI:10.1007/s00044-010-9494-z

upstream raw materials:

aceclofenac

Downstream raw materials:

C₁₇H₁₃Cl₂N₃O₃S

[5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate