[5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate

Base Information

• Chemical Name: [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate
• CAS No.: 1262801-24-0
• Molecular Formula: C₂₈H₁₉Cl₂N₃O₆S
• Molecular Weight: 596.447
• Mol file: 1262801-24-0.mol

Synonyms:

Chemical Property of [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate

There total 6 articles about [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-bromoacetylcoumarin (29310-88-1) + C17H13Cl2N3O3S (1262801-30-8) → [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate (1262801-24-0)

Guidance literature:

C₁₇H₁₃Cl₂N₃O₃S; With sodium ethanolate; In ethanol; for 4h; Reflux;

3-bromoacetylcoumarin; In ethanol; Reflux;

DOI:10.1007/s00044-010-9494-z

Reference yield:

2-methoxy-2-oxoethyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate (139272-66-5) → [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate (1262801-24-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / Reflux

2.1: potassium hydroxide / methanol / 12 h / Reflux

3.1: sodium ethanolate / ethanol / 4 h / Reflux

3.2: Reflux

With hydrazine hydrate; sodium ethanolate; potassium hydroxide; In methanol; ethanol;

DOI:10.1007/s00044-010-9494-z

Reference yield:

2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide (1332717-20-0) → [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate (1262801-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 12 h / Reflux

2.1: sodium ethanolate / ethanol / 4 h / Reflux

2.2: Reflux

With sodium ethanolate; potassium hydroxide; In methanol; ethanol;

DOI:10.1007/s00044-010-9494-z

upstream raw materials:

2-methoxy-2-oxoethyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate

2-[(2',6'-dichlorophenyl)amino]phenyl acetoxyacetyl hydrazide

3-bromoacetylcoumarin

C₁₇H₁₃Cl₂N₃O₃S