(S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole

Base Information

• Chemical Name: (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole
• CAS No.: 154774-33-1
• Molecular Formula: C₁₉H₂₇NO₂Si
• Molecular Weight: 329.514

Synonyms:(S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole

Chemical Property of (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole

There total 2 articles about (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

t-butyldimethylsiyl triflate (69739-34-0) + (3S,7aR)-6-Methyl-3-phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one (154774-32-0) → (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole (154774-33-1)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; Ambient temperature;

DOI:10.1021/ja00084a062

Reference yield:

(2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one (118918-76-6,1820583-17-2) → (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole (154774-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA, 2.) LDA, PhSeBr, 3.) O₃

2: 89 percent / 2,6-lutidine / CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; Phenylselenyl bromide; ozone; lithium diisopropyl amide; In dichloromethane;

DOI:10.1021/ja00084a062

Reference yield: 55.0%

isobutyraldehyde (78-84-2) + (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole (154774-33-1) → (3S,7aR)-7a-((R)-1-Hydroxy-2-methyl-propyl)-6-methyl-3-phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one + (3S,7aR)-7a-((S)-1-Hydroxy-2-methyl-propyl)-6-methyl-3-phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one (154774-34-2)

Guidance literature:

With tin(IV) chloride; In diethyl ether; at -78 ℃;

DOI:10.1021/ja00084a062

upstream raw materials:

t-butyldimethylsiyl triflate

(3S,7aR)-6-Methyl-3-phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one

(2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one

Downstream raw materials:

(3S,7aR)-7a-((S)-1-Hydroxy-2-methyl-propyl)-6-methyl-3-phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one

(3R,4S,5R,1'S)-4-hydroxy-5-(1'-hydroxy-2'-methylpropyl)-3-methylpyrrolidin-2-one-5-carboxylic acid

Lactacystin

Acetic acid (S)-2-methyl-1-((3S,7aR)-6-methyl-5-oxo-3-phenyl-5H-pyrrolo[1,2-c]oxazol-7a-yl)-propyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 154774-33-1 (S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-3-phenyl-1H-pyrrolo[1,2-c]oxazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send