4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

Base Information

Chemical Name:4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide
CAS No.:600135-81-7
Molecular Formula:C₂₁H₂₄N₄O₅
Molecular Weight:412.445
Hs Code.:

4-cyano-<i>N</i>-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

Synonyms:4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

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Chemical Property of 4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

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Technology Process of 4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

There total 2 articles about 4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131906-15-5
γ-cyano-3-phenylbutanoic acid

: 600135-81-7
4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N'-dicyclohexyl carbodiimide / dimethylformamide / 1.5 h / 50 °C

2: 284 mg / dimethylformamide

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1016/S0022-328X(02)02100-9

Reference yield:

: 25152-20-9
5'-amino-5'-deoxythymidine

: 4-cyano-3-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

: 600135-81-7
4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

Guidance literature:: In N,N-dimethyl-formamide;
DOI:10.1016/S0022-328X(02)02100-9

Reference yield: 98.0%

: 600135-81-7
4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

: 550312-85-1
5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h;
DOI:10.1016/S0022-328X(02)02100-9