N^α-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester

Base Information

• Chemical Name: N^α-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester
• CAS No.: 1380302-80-6
• Molecular Formula: C₃₈H₄₀N₄O₁₂
• Molecular Weight: 744.755
• Mol file: 1380302-80-6.mol

Synonyms:N^α-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester

Chemical Property of N^α-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester

There total 1 articles about N^α-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranosyl bromide (67673-39-6) + N-(fluoren-9-ylmethoxycarbonyl)-L-threonine benzyl ester (73724-48-8) → Nα-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester (1380302-80-6)

Guidance literature:

N-(fluoren-9-ylmethoxycarbonyl)-L-threonine benzyl ester; With silver perchlorate; silver carbonate; In dichloromethane; toluene; at 20 ℃; for 1.08333h; Molecular sieve; Inert atmosphere;

3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranosyl bromide; In dichloromethane; toluene; at 20 ℃; for 96h; Molecular sieve; Inert atmosphere;

DOI:10.1007/s10719-011-9353-2

Reference yield: 70.0%

Nα-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester (1380302-80-6) + tiolacetic acid (507-09-5) → Nα-fluoren-9-ylmethoxycarbonyl-O-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threoninebenzyl ester (100938-56-5)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1039/c7ob02976d

Reference yield:

Nα-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine benzyl ester (1380302-80-6) → Nα-fluoren-9-ylmethoxycarbonyl-O-(2-azido-2-deoxy-α-D-galactopyranosyl)-L-threonine benzyl ester (218291-41-9)

Guidance literature:

With methanol; sodium methylate; at 0 ℃; for 2h;

DOI:10.1007/s10719-017-9781-8

upstream raw materials:

3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranosyl bromide

N-(fluoren-9-ylmethoxycarbonyl)-L-threonine benzyl ester

Downstream raw materials:

N-(9H-fluoren-9-yl)methoxycarbonyl-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-threonine

N^α-fluoren-9-ylmethoxycarbonyl-O-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threoninebenzyl ester

N^α-fluoren-9-ylmethoxycarbonyl-O-(2-azido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranosyl)-L-threonine benzyl ester

N^α-fluoren-9-ylmethoxycarbonyl-O-[2-azido-4,6-O-benzylidene-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl]-L-threonine benzyl ester

Refernces