4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Base Information

Chemical Name:4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
CAS No.:1289626-09-0
Molecular Formula:C₁₇H₂₄BrNO₅S
Molecular Weight:434.351
Hs Code.:

Synonyms:4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Chemical Property of 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Technology Process of 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

There total 4 articles about 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1289626-08-9
4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid

: 1289626-09-0
4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid; With benzotriazol-1-ol; triethylamine; In dichloromethane; for 0.166667h;

O-2-tetrahydro-2H-pyranhydroxylamine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 12h;

Reference yield:

: 4654-39-1
4-bromophenethanol

: 1289626-09-0
4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 1 h / 0 - 25 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 0 - 25 °C

3.2: pH 4

4.1: triethylamine; benzotriazol-1-ol / dichloromethane / 0.17 h

4.2: 12 h

With 1H-imidazole; water; iodine; benzotriazol-1-ol; caesium carbonate; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 85356-68-9
1-bromo-4-(2-iodoethyl)benzene

: 1289626-09-0
4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 0 - 25 °C

2.2: pH 4

3.1: triethylamine; benzotriazol-1-ol / dichloromethane / 0.17 h

3.2: 12 h

With water; benzotriazol-1-ol; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;