1-(2-fluorophenyl)-3-methyl-1H-pyrazol-5-amine

Base Information

• Chemical Name: 1-(2-fluorophenyl)-3-methyl-1H-pyrazol-5-amine
• CAS No.: 105438-46-8
• Molecular Formula: C₁₀H₁₀FN₃
• Molecular Weight: 191.208
• Hs Code.: 2933199090
• DSSTox Substance ID: DTXSID101247260
• Mol file: 105438-46-8.mol

Synonyms:1-(2-fluorophenyl)-3-methyl-1H-pyrazol-5-amine;105438-46-8;2-(2-FLUOROPHENYL)-5-METHYLPYRAZOL-3-AMINE;1H-Pyrazol-5-amine, 1-(2-fluorophenyl)-3-methyl-;SCHEMBL10925409;DTXSID101247260;MFCD02091542;AKOS000125380;KS-6869;SY115438;CS-0449330;EN300-57792;G41018;1-(2-Fluorophenyl)-3-methyl-1H-pyrazol-5-ylamine;F2113-0746;1-(2-Fluorophenyl)-3-methyl-1H-pyrazol-5-amine, AldrichCPR

Chemical Property of 1-(2-fluorophenyl)-3-methyl-1H-pyrazol-5-amine

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 191.08587549
• Heavy Atom Count: 14
• Complexity: 200

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Fluorophenyl)-3-methyl-1H-pyrazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NN(C(=C1)N)C2=CC=CC=C2F

Technology Process of 1-(2-fluorophenyl)-3-methyl-1H-pyrazol-5-amine

There total 1 articles about 1-(2-fluorophenyl)-3-methyl-1H-pyrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-Aminocrotononitrile (1118-61-2) + 2-fluorophenylhydrazine (2368-80-1) → 3-methyl-1-(2-fluorophenyl)-1H-pyrazol-5-amine (105438-46-8)

Guidance literature:

3-Aminocrotononitrile; 2-fluorophenylhydrazine; With hydrogenchloride; In water; for 12h; Reflux;

With sodium hydroxide; In water;

DOI:10.1016/j.bmc.2012.04.021

Reference yield: 82.0%

acetic anhydride (108-24-7) + 3-methyl-1-(2-fluorophenyl)-1H-pyrazol-5-amine (105438-46-8) → 5-Acetamido-1-(2-fluorophenyl)-3-methylpyrazole (105438-73-1)

Guidance literature:

at 100 ℃;

DOI:10.1016/S0040-4020(01)87774-7

Reference yield: 68.0%

3-methyl-1-(2-fluorophenyl)-1H-pyrazol-5-amine (105438-46-8) + benzoyl chloride (98-88-4) → 5-Benzamido-1-(2-fluorophenyl)-3-methylpyrazole (105438-74-2)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 60 ℃; for 4h;

DOI:10.1016/S0040-4020(01)87774-7

upstream raw materials:

3-Aminocrotononitrile

2-fluorophenylhydrazine

Downstream raw materials:

5-Acetamido-1-(2-fluorophenyl)-3-methylpyrazole

5-Benzamido-1-(2-fluorophenyl)-3-methylpyrazole

5-Ethylamino-1-(2-fluorophenyl)-3-methylpyrazole

1-(2-Fluoro-phenyl)-3,5-dimethyl-1,6-dihydro-imidazo[4,5-c]pyrazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 105438-46-8 3-methyl-1-(2-fluorophenyl)-1H-pyrazol-5-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send