(R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate

Base Information

• Chemical Name: (R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate
• CAS No.: 1610850-93-5
• Molecular Formula: C₁₉H₂₈N₂O₅
• Molecular Weight: 364.442

Synonyms:(R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate

Chemical Property of (R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate

Chemical Property:

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Technology Process of (R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate

There total 2 articles about (R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-tert-butoxycarbonyl-N-methyl-D-phenylalanine (37553-65-4,64263-83-8,85466-66-6) + N-methylglycine methyl ester hydrochloride (13515-93-0) → (R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate (1610850-93-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 22h;

DOI:10.1021/acs.orglett.8b00576

Reference yield: 79.0%

(R)-methyl 2-(2-(tert-butoxycarbonylamino)-3-phenylpropanamido)acetate (26582-93-4) + methyl iodide (74-88-4) → (R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate (1610850-93-5)

Guidance literature:

With silver(l) oxide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2014.04.079

Reference yield:

(R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate (1610850-93-5) + trifluoroacetic acid (76-05-1) → C14H20N2O3*C2HF3O2 (1610850-95-7)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2014.04.079

upstream raw materials:

(R)-methyl 2-(2-(tert-butoxycarbonylamino)-3-phenylpropanamido)acetate

methyl iodide

N-tert-butoxycarbonyl-N-methyl-D-phenylalanine

N-methylglycine methyl ester hydrochloride

Downstream raw materials:

Boc-Ala-D-Phe(N-Me)-Gly(N-Me)-Ile-Ala(N-Me)-OMe

Boc-Ala-D-Phe(N-Me)-Gly(N-Me)-Ile-Ala(N-Me)-OBn

C₅₄H₉₁N₅O₁₂Si

C₆₀H₉₅N₅O₁₂Si

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