O-(2-bromobenzyl) 2-methyl carbonothioate

Base Information

• Chemical Name: O-(2-bromobenzyl) 2-methyl carbonothioate
• CAS No.: 500372-18-9
• Molecular Formula: C₉H₉BrO₂S
• Molecular Weight: 261.139
• Mol file: 500372-18-9.mol

Synonyms:O-(2-bromobenzyl) 2-methyl carbonothioate

Chemical Property of O-(2-bromobenzyl) 2-methyl carbonothioate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(2-bromobenzyl) 2-methyl carbonothioate

There total 4 articles about O-(2-bromobenzyl) 2-methyl carbonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

carbon monoxide (201230-82-2) + o-bromobenzyl alcohol (18982-54-2) + methyl iodide (74-88-4) → O-(2-bromobenzyl) 2-methyl carbonothioate (500372-18-9)

Guidance literature:

carbon monoxide; o-bromobenzyl alcohol; With sulfur; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 80 ℃; for 6h; under 7500.6 Torr;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 16h; under 750.06 Torr;

DOI:10.1016/S0040-4020(02)01331-5

Reference yield: 87.0%

carbon oxide sulfide (463-58-1) + o-bromobenzyl alcohol (18982-54-2) + methyl iodide (74-88-4) → O-(2-bromobenzyl) 2-methyl carbonothioate (500372-18-9)

Guidance literature:

carbon oxide sulfide; o-bromobenzyl alcohol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 1h; under 750.06 Torr;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 2h; under 750.06 Torr;

DOI:10.1016/S0040-4020(02)01331-5

Reference yield:

thiocarbonic acid O-(2-bromo-benzyl) ester + methyl iodide (74-88-4) → O-(2-bromobenzyl) 2-methyl carbonothioate (500372-18-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h; under 750.06 Torr;

DOI:10.1016/S0040-4039(02)01834-8

upstream raw materials:

carbon oxide sulfide

o-bromobenzyl alcohol

methyl iodide

carbon monoxide

Downstream raw materials:

o-bromobenzyl chloroformate

Refernces

• 1、 Mizuno, Takumi,Takahashi, Junko,Ogawa, Akiya. "Benzyl chloroformate (CbzCl) synthesis using carbon monoxide as a carbonyl source". . p. 10011 - 10015. Retrieved 2007/10/03.