rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

Base Information

Chemical Name:rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone
CAS No.:1439557-63-7
Molecular Formula:C₂₃H₂₃NO₂
Molecular Weight:345.441
Hs Code.:

Synonyms:rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

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Technology Process of rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

There total 5 articles about rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 590-93-2
2-Butynoic acid

: 1439557-55-7
rac-2-(4-bromo-2,6-dimethylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

: 1439557-63-7
rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; dimethyl sulfoxide; at 110 ℃; for 0.666667h; Inert atmosphere;

Reference yield:

: 1439557-55-7
rac-2-(4-bromo-2,6-dimethylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

: 64099-82-7
1-propynyltributylstannane

: 1439557-63-7
rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 130 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: C₂₁H₂₂BrNO₅S

: 1439557-63-7
rac-2-(2,6-dimethyl-4-prop-1-ynylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol / 25 - 30 °C

2: acetic acid; zinc / 25 - 30 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; zinc; In methanol; toluene;