3'-(2,4-Difluorophenoxy)-4'-nitroacetophenone

Base Information

Chemical Name:3'-(2,4-Difluorophenoxy)-4'-nitroacetophenone
CAS No.:116686-85-2
Molecular Formula:C₁₄H₉F₂NO₄
Molecular Weight:293.227
Hs Code.:
DSSTox Substance ID:DTXSID901231708

Synonyms:SCHEMBL9656755;VICWBLNIZFWGJL-UHFFFAOYSA-N;DTXSID901231708;3'-(2,4-difluorophenoxy)-4'-nitroacetophenone;1-[3-(2,4-difluorophenoxy)-4-nitrophenyl]ethanone;116686-85-2

Suppliers and Price of 3'-(2,4-Difluorophenoxy)-4'-nitroacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3'-(2,4-Difluorophenoxy)-4'-nitroacetophenone

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:293.04996409
Heavy Atom Count:21
Complexity:401

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=CC(=C(C=C1)[N+](=O)[O-])OC2=C(C=C(C=C2)F)F

Technology Process of 3'-(2,4-Difluorophenoxy)-4'-nitroacetophenone

There total 6 articles about 3'-(2,4-Difluorophenoxy)-4'-nitroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 367-27-1
2,4-difluorophenol

: 116686-84-1
3'-chloro-4-nitroacetophenone

: 116686-85-2
3'-(2,4-difluorophenoxy)-4'-nitroacetophenone

Guidance literature:: With potassium carbonate; In xylene; for 5.5h; Heating;
DOI:10.1248/cpb.40.2399

Reference yield:

: 6953-83-9
1-(4-amino-3-chlorophenyl)ethan-1-one

: 116686-85-2
3'-(2,4-difluorophenoxy)-4'-nitroacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium nitrite, aq. HCl, 2.) sodium nitrite, cuprous oxide / 1.) from -5 deg C to 0 deg C, 10 min, 2.) H₂O, from -5 deg C to RT, 60 min

2: 60 percent / potassium carbonate / xylene / 5.5 h / Heating

With copper(I) oxide; hydrogenchloride; potassium carbonate; sodium nitrite; In xylene;
DOI:10.1248/cpb.40.2399