1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE

Base Information

• Chemical Name: 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE
• CAS No.: 6953-83-9
• Molecular Formula: C8H8ClNO
• Molecular Weight: 169.611
• Hs Code.: 2922399090
• Mol file: 6953-83-9.mol

Synonyms:Acetophenone,4'-amino-3'-chloro- (5CI);3'-Chloro-4'-aminoacetophenone;4-Amino-3-chloroacetophenone;NSC 39777;

Chemical Property of 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE

Chemical Property:

• Vapor Pressure: 0.000243mmHg at 25°C
• Refractive Index: 1.586
• Boiling Point: 324.6 °C at 760 mmHg
• PKA: 0.22±0.10(Predicted)
• Flash Point: 150.1 °C
• PSA: 43.09000
• Density: 1.254 g/cm³
• LogP: 2.70600

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Amino-3-chlorophenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE

There total 10 articles about 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(2-chlorophenyl)acetamide (533-17-5) → 1-(4-amino-3-chlorophenyl)ethan-1-one (6953-83-9)

Guidance literature:

With aluminium trichloride; for 0.0583333h; microwave irradiation;

Reference yield: 85.0%

p-aminobenzophenone (99-92-3) → 1-(4-amino-3-chlorophenyl)ethan-1-one (6953-83-9)

Guidance literature:

With 2,4,6-tris[(4-dichloroiodo)phenoxy]-1,3,5-triazine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1055/s-0033-1339495

Reference yield: 80.0%

p-aminobenzophenone (99-92-3) → 1-(4-amino-3-chlorophenyl)ethan-1-one (6953-83-9) + 1-(4-amino-3,5-dichlorophenyl)-1-ethanone (37148-48-4)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 3.5h;

upstream raw materials:

N-[2-chloro-4-acetyl-phenyl]-acetamide

3',4'-dichloroacetophenone

N-(2-chlorophenyl)acetamide

p-aminobenzophenone

Downstream raw materials:

3'-chloro-4-nitroacetophenone

4-amino-3-bromo-5-chloroacetophenone

bromoclenbuterol