4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Chemical Name:4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide
CAS No.:1374675-06-5
Molecular Formula:C₂₀H₁₆ClF₆N₅O₄S
Molecular Weight:571.888
Hs Code.:

Synonyms:4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Chemical Property of 4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Technology Process of 4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

There total 7 articles about 4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 75-89-8
2,2,2-trifluoroethanol

: 1374675-04-3
4-[(S)-3-(2-chloro-4-fluoro-benzenesulfonyl)-pyrrolidin-1-yl]-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

: 1374675-06-5
4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

Reference yield:

: 2972-52-3
2,4-dichloropyrimidine-5-carbonyl chloride

: 1374675-06-5
4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 25 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

3: 1,4-diaza-bicyclo[2.2.2]octane; water / dimethyl sulfoxide / 1 h / 80 °C

4: caesium carbonate / N,N-dimethyl-formamide / 24 h / 25 °C

With 1,4-diaza-bicyclo[2.2.2]octane; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1374675-76-9
(S)-3-(2-Chloro-4-fluoro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1374675-06-5
4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-2-cyano-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C

2.1: formic acid / 4 h / 25 °C

2.2: pH 8

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

4.1: 1,4-diaza-bicyclo[2.2.2]octane; water / dimethyl sulfoxide / 1 h / 80 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 25 °C

With 1,4-diaza-bicyclo[2.2.2]octane; formic acid; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;