2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine

Base Information

Chemical Name:2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine
CAS No.:871339-20-7
Molecular Formula:C₁₅H₂₄ClN₃O₂
Molecular Weight:313.827
Hs Code.:

Synonyms:2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine

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Chemical Property of 2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine

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Technology Process of 2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine

There total 5 articles about 2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-85-0
piperazine

: 871339-19-4
2-{[3-bromo-5-chloro-2-(methyloxy)phenyl]oxy}-N,N-dimethylethanamine

: 871339-20-7
2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 5h; Heating / reflux;

Reference yield:

: 871339-18-3
3-bromo-5-chloro-2-(methyloxy)phenol

: 871339-20-7
2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 - 70 °C

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / Heating / reflux

With caesium carbonate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 871339-17-2
[3-bromo-5-chloro-2-(methyloxy)phenyl]methanol

: 871339-20-7
2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hypochlorite; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / dichloromethane; water / 0.33 h / 0 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 26 h / Heating / reflux

3: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 - 70 °C

4: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / Heating / reflux

With sodium hypochlorite; sodium hydrogencarbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium bromide; In dichloromethane; water; N,N-dimethyl-formamide; toluene;