871339-18-3

Upstream product

• 25299-26-7 3-bromo-5-chloro-2-(methyloxy)benzaldehyde 
• 88275-88-1 3-bromo-2-methoxyphenol 
• 1404575-81-0 C₈H₉BrO₃ 
• 65851-97-0 methyl 3-bromo-5-chloro-2-methoxybenzoate 
• 871339-17-2 [3-bromo-5-chloro-2-(methyloxy)phenyl]methanol 

Downstream Products

• 871339-19-4 2-{[3-bromo-5-chloro-2-(methyloxy)phenyl]oxy}-N,N-dimethylethanamine 
• 871339-20-7 2-{[5-chloro-2-(methyloxy)-3-piperazin-1-ylphenyl]oxy}-N,N-dimethylethanamine 

Relevant academic research and scientific papers

Unanticipated participation of HCl in nucleophilic chlorination reaction: Expedient route to meta chlorophenols

o-Quinone monoketals participated in a 1,4-addition reaction with HCl furnishing m-chlorophenols in high yields. Several readily available o-quinone monoketals were selected to display the generality of this serendipitous and unprecedented reaction and the results are presented herein.

KINASE MODULATORS AND METHODS OF USE

The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.