Technology Process of (9E,11S,12S)-12-[(1E)-3-benzyloxy-1-methylprop-1-en-1-yl]-8-{[tert-butyl(dimethyl)silyl]oxy}-1,1'-dimethylazacyclododec-9-en-2-one
There total 20 articles about (9E,11S,12S)-12-[(1E)-3-benzyloxy-1-methylprop-1-en-1-yl]-8-{[tert-butyl(dimethyl)silyl]oxy}-1,1'-dimethylazacyclododec-9-en-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1H-imidazole;
nickel dichloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C
3: hydrogenchloride / water
4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 19.5 h / 20 °C
6: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
7: chromium dichloride / nickel dichloride / N,N-dimethyl-formamide / 13 h / 20 °C
8: 1H-imidazole / nickel dichloride / N,N-dimethyl-formamide / 24 h / 20 °C
With
1H-imidazole; chromium dichloride; hydrogenchloride; lithium hydroxide; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; Dess-Martin periodane; diisopropylamine;
nickel dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
7: Nozaki-Hiyama-Kishi Coupling;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: formic acid; triethylamine / 21 h / 50 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C
3: lithium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C
4: hydrogenchloride / water
5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
6: tetrabutyl ammonium fluoride / tetrahydrofuran / 19.5 h / 20 °C
7: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
8: chromium dichloride / nickel dichloride / N,N-dimethyl-formamide / 13 h / 20 °C
9: 1H-imidazole / nickel dichloride / N,N-dimethyl-formamide / 24 h / 20 °C
With
1H-imidazole; chromium dichloride; hydrogenchloride; lithium hydroxide; formic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; Dess-Martin periodane; triethylamine; diisopropylamine;
nickel dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
8: Nozaki-Hiyama-Kishi Coupling;
