6149-48-0

Usage

InChI:InChI=1/C21H22N4O4S/c1-3-29-16-10-8-15(9-11-16)23-19(26)12-18-20(27)24-21(30-18)25-22-13-14-6-4-5-7-17(14)28-2/h4-11,13,18H,3,12H2,1-2H3,(H,23,26)(H,24,25,27)/b22-13+

Upstream product

• 33018-91-6 7-ethoxy-7-oxoheptanoic acid 
• 76-05-1 trifluoroacetic acid 
• 502-42-1 cycloheptanone 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 25118-23-4 ethyl 6-heptenoate 
• 22054-13-3 7-hydroxyheptanal 
• 627-27-0 homoalylic alcohol 
• 201230-82-2 carbon monoxide 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 29823-18-5 ethyl 7-bromoheptanoate 
• 120-92-3 cyclopentanone 
• 108-94-1 cyclohexanone 
• 694-54-2 tetrahydro-2H-2-pyranol 

Downstream Products

• 25118-23-4 ethyl 6-heptenoate 
• 1070-64-0 6,8-dichlorooctanoic acid ethyl ester 
• 77744-45-7 7-((tert-butyldimethylsilyl)oxy)heptanoic acid 
• 1072090-99-3 (2S,3S,4E)-2-((1E,3E,5S)-6-{(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]oxiran-2-yl}-1,5-dimethylhexa-1,3-dien-1-yl)-1,3-dimethyl-12-oxaazacyclododec-4-en-6-yl acetate 
• 1072091-39-4 (9E,11S,12S)-12-[(1E)-3-benzyloxy-1-methylprop-1-en-1-yl]-8-{[tert-butyl(dimethyl)silyl]oxy}-1,1'-dimethylazacyclododec-9-en-2-one 
• 1072091-37-2 N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxy-N-methylheptanamide 
• 1072091-40-7 C₂₄H₃₄INO₃ 
• 1072091-41-8 C₂₄H₃₅NO₃ 
• 1072091-44-1 (2S,3S,4E)-1,3-dimethyl-2-[(1E)-1-methylbuta-1,3-dien-1-yl]-12-oxoazacylododec-4-en-6-yl acetate 
• 1072091-45-2 C₁₈H₂₉NO₂ 
• 728890-58-2 7-oxoheptanoic acid phenylamide 
• 19307-16-5 Octadec-17-ensaeure 
• 57267-45-5 (7-ethoxy-7-oxoheptyl)-triphenylphosphonium bromide 
• 147219-90-7 Benzoic acid (E)-(R)-9-ethoxycarbonyl-1-octyl-non-2-enyl ester 

Relevant academic research and scientific papers

Method for preparing 6,8-dichloroethyl caprylate

The invention provides a method for preparing 6,8-dichloroethyl caprylate. As shown in the following reaction formula, the method comprises the following reaction: performing oxidative esterificationon a compound 1 to obtain a compound 2, dehydrating to generate a compound 3, performing a Prins condensation reaction to obtain a compound 4, performing hydrolysis hydrogenation to obtain a compound5, and finally performing chlorination to obtain the 6,8-dichloroethyl caprylate. The method has the characteristics of easily available raw materials, simple process, high efficiency and environmental protection.

Synthesis and biological evaluation of aziridin-1-yl oxime-based vorinostat analogs as anticancer agents

The suberoyl anilide hydroxamic acid (vorinostat) analogs with the aziridin-1-yl oxime moiety as a possible metal chelating functionality have been synthesized. Their biological activity and stability under physiological conditions have been evaluated. Although some of the synthesized compounds demonstrated high antiproliferative activity against human HT1080 fibrosarcoma (HT1080, IC50 0.3-7.7 μM) comparable to vorinostat (HT1080, IC50 2.4 μM), they showed only weak histone deacetylase inhibition activity in HeLa cell line extracts.

New phosphorus self-assembling ligands for the tandem hydroformylation- Wittig olefination reaction of homoallylic alcohols - A key step for stereoselective pyran synthesis

New self-assembled phosphorus ligands are synthesized and used in the rhodium complex catalyzed hydroformylation-Wittig reaction of homoallylic olefins under optimized condition. A subsequent oxa-Michael intramolecular reaction yields β-pyran derivatives (conversion and diastereoselectivity up to 99%).

MODULATORS OF OCULAR OXIDATIVE STRESS

Described herein are compounds, compositions and methods directed to the treatment of ophthalmic conditions characterized by oxidative stress or damage in a subject by reducing the reactive oxygen species in the subject. Also described herein are methods for reducing ophthalmic photooxidative damage in a subject.

12 MEMBERED-RING MACROLACTAM DERIVATIVES

There provided a 12-membered-ring macrolactam derivative having antitumor activity: A compound represented by Formula (1) or a salt thereof. In this Formula, R1 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl

Titanium(III) mediated regiospecific reduction of vinyl epoxides

A highly regiospecific reduction of vinyl epoxides to allyl alcohols with Cp2TiCl is described.

An improved and simple synthesis of methyl or ethyl 7-oxoheptanoate and 7-acetoxyheptanal

Reaction of cycloheptanone with potassium persulfate, in ethanol or methanol, gave ethyl or methyl 7-hydroxyheptanoate which, by oxidation with PCC, were converted into ethyl or methyl 7-oxoheptanoate in good yields. Protection of aldehyde group of methyl 7-oxoheptanoate, followed by one-step conversion of carboxylic ester to the acetate gave, after regeneration of aldehyde group, 7-acetoxyheptanal.