1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

Base Information

• Chemical Name: 1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane
• CAS No.: 439614-41-2
• Molecular Formula: C₅₀H₅₀Br₃N₁₁O₂
• Molecular Weight: 1076.73
• Mol file: 439614-41-2.mol

Synonyms:1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

Chemical Property of 1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

There total 3 articles about 1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

6-bromo-5'-bromomethyl-2,2'-bipyridine (334001-82-0) + 1-(3-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane (439614-40-1) → 1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane (439614-41-2)

Guidance literature:

With sodium carbonate; In acetonitrile; at 80 ℃; for 72h;

DOI:10.1021/jo0200015

Reference yield:

1,4,8,11-Tetraazacyclotetradecane (295-37-4) → 1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane (439614-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / toluene / 0.67 h / heating

2: 63 percent / Na₂CO₃ / acetonitrile / 72 h / 80 °C

With sodium carbonate; In toluene; acetonitrile;

DOI:10.1021/jo0200015

Reference yield:

1-bromomethyl-3-nitrobenzene (3958-57-4) → 1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane (439614-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / toluene / 0.67 h / heating

2: 63 percent / Na₂CO₃ / acetonitrile / 72 h / 80 °C

With sodium carbonate; In toluene; acetonitrile;

DOI:10.1021/jo0200015

upstream raw materials:

6-bromo-5'-bromomethyl-2,2'-bipyridine

1-(3-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane

1,4,8,11-Tetraazacyclotetradecane

1-bromomethyl-3-nitrobenzene

Downstream raw materials:

1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane