1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

Base Information

Chemical Name:1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane
CAS No.:439614-42-3
Molecular Formula:C₅₉H₆₅N₁₁O₈
Molecular Weight:1056.23
Hs Code.:

Synonyms:1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

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Chemical Property of 1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

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Technology Process of 1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

There total 4 articles about 1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 439614-41-2
1-(3-nitrobenzyl)-4,8,11-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

: 439614-42-3
1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; at 80 ℃; under 760.051 Torr;
DOI:10.1021/jo0200015

Reference yield:

: 295-37-4
1,4,8,11-Tetraazacyclotetradecane

: 439614-42-3
1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / toluene / 0.67 h / heating

2: 63 percent / Na₂CO₃ / acetonitrile / 72 h / 80 °C

3: 76 percent / Et₃N / Pd(PPh₃)2Cl₂ / CH₂Cl₂ / 80 °C / 760.05 Torr

With sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo0200015

Reference yield:

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 439614-42-3
1-(3-nitrobenzyl)-4,8,11-tris[(6-carboethoxy-2,2'-bipyridine-5'-yl)methyl]-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / toluene / 0.67 h / heating

2: 63 percent / Na₂CO₃ / acetonitrile / 72 h / 80 °C

3: 76 percent / Et₃N / Pd(PPh₃)2Cl₂ / CH₂Cl₂ / 80 °C / 760.05 Torr

With sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo0200015