3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

Base Information

Chemical Name:3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride
CAS No.:1255148-27-6
Molecular Formula:C₂₇H₂₄N₄O₆*ClH
Molecular Weight:536.972
Hs Code.:

Synonyms:3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

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Chemical Property of 3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

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Technology Process of 3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

There total 9 articles about 3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255149-56-4
3-(4-aminophenyl)-2-furan carboxylic acid 2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

: 122-00-9
para-methylacetophenone

: 1255148-27-6
3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

Guidance literature:: 3-(4-aminophenyl)-2-furan carboxylic acid 2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride; para-methylacetophenone; With 2-picoline borane complex; sodium acetate; In methanol; acetic acid; at 40 ℃; for 5h;

With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield:

: 405277-41-0
4-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)aniline

: 1255148-27-6
3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 48 h / Reflux; Inert atmosphere

2.1: hydrazine / 1,4-dioxane; ethanol / 6 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

4.1: hydrogenchloride / isopropyl alcohol; 1,4-dioxane; tetrahydrofuran / 8 h / 20 °C

5.1: sodium acetate; 2-picoline borane complex / acetic acid; methanol / 5 h / 40 °C

5.2: 20 °C

With hydrogenchloride; 2-picoline borane complex; sodium acetate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 32460-07-4
ethyl 3-bromofuran-2-carboxylate

: 1255148-27-6
3-(4-{[1-(4-methylphenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 48 h / Reflux; Inert atmosphere

2.1: hydrazine / 1,4-dioxane; ethanol / 6 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

4.1: hydrogenchloride / isopropyl alcohol; 1,4-dioxane; tetrahydrofuran / 8 h / 20 °C

5.1: sodium acetate; 2-picoline borane complex / acetic acid; methanol / 5 h / 40 °C

5.2: 20 °C

With hydrogenchloride; 2-picoline borane complex; sodium acetate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;