(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

Base Information

Chemical Name:(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate
CAS No.:1335386-72-5
Molecular Formula:C₃₂H₃₉ClN₂O₇S
Molecular Weight:631.19
Hs Code.:

Synonyms:(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

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Chemical Property of (S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

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Technology Process of (S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

There total 12 articles about (S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335387-28-4
C₂₆H₃₅IN₂O₇S

: 1679-18-1
4-Chlorophenylboronic acid

: 1335386-72-5
(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

Guidance literature:: With palladium 10% on activated carbon; potassium carbonate; In ethanol; water; toluene; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: 1335387-17-1
C₁₅H₁₉ClINO₃

: 1335386-72-5
(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / ethanol / -78 °C

2: potassium carbonate / methanol

3: ethanol

4: sodium hydrogencarbonate / dichloromethane; water

5: hydrogenchloride / 1,4-dioxane

6: bis(trichloromethyl) carbonate; triethylamine / dichloromethane

7: palladium 10% on activated carbon; potassium carbonate / ethanol; water; toluene / 8 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; bis(trichloromethyl) carbonate; palladium 10% on activated carbon; sodium hydrogencarbonate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 7: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: C₁₆H₁₉INO₅^(1-)*Na⁽¹⁺⁾

: 1335386-72-5
(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride / water

2: sodium tetrahydroborate / ethanol / -78 °C

3: potassium carbonate / methanol

4: ethanol

5: sodium hydrogencarbonate / dichloromethane; water

6: hydrogenchloride / 1,4-dioxane

7: bis(trichloromethyl) carbonate; triethylamine / dichloromethane

8: palladium 10% on activated carbon; potassium carbonate / ethanol; water; toluene / 8 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; bis(trichloromethyl) carbonate; palladium 10% on activated carbon; sodium hydrogencarbonate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 8: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037