tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate
CAS No.:915795-74-3
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

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Chemical Property of tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

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Technology Process of tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

There total 2 articles about tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 915302-93-1
2-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-4-carboxylic acid tert-butyl ester

: 915795-74-3
tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield: 23.0%

: 915302-93-1
2-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-4-carboxylic acid tert-butyl ester

: 915795-74-3
tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

Guidance literature:: 2-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-4-carboxylic acid tert-butyl ester; With formaldehyd; sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

With water; citric acid; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield: 84.0%

: 915795-74-3
tert-butyl 3-(hydroxymethyl)-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

: 105-36-2
ethyl bromoacetate

: 1037368-59-4
tert-butyl (3S)-3-[(2-ethoxy-2-oxoethoxy)methyl]-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 18.5h;
DOI:10.1021/acs.jmedchem.8b00644