N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide

Base Information

Chemical Name:N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide
CAS No.:1443237-01-1
Molecular Formula:C₂₃H₂₁N₅O
Molecular Weight:383.453
Hs Code.:

Synonyms:N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide

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Chemical Property of N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide

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Technology Process of N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide

There total 6 articles about N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 489446-42-6
4-((tert-butoxycarbonylamino)methyl)phenylboronic acid

: 79-41-4,25087-26-7,50867-57-7
poly(methacrylic acid)

: 1443237-67-9
3-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

: 1443237-01-1
N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide

Guidance literature:: 4-((tert-butoxycarbonylamino)methyl)phenylboronic acid; 3-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline; With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 110 ℃; for 17h; Inert atmosphere;

In 1,4-dioxane; at 15 - 25 ℃; for 20h; Inert atmosphere;

poly(methacrylic acid); With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; at 15 - 25 ℃; for 70h; Inert atmosphere;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1443237-01-1
N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide / 1 h / 115 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h

3.1: hydrogen; 3 % platinum on carbon / methanol / 18 h

4.1: KH₂PO₄; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 17 h / 110 °C

4.2: SiliaMetS?; DMT / 20 h

5.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 70 h

With KH₂PO₄; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 3 % platinum on carbon; hydrogen; sodium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1517/13543776.2014.851670

Reference yield:

: 13331-27-6
m-nitrobenzene boronic acid

: 1443237-01-1
N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide / 1 h / 115 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h

3.1: hydrogen; 3 % platinum on carbon / methanol / 18 h

4.1: KH₂PO₄; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 17 h / 110 °C

4.2: SiliaMetS?; DMT / 20 h

5.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 70 h

With KH₂PO₄; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 3 % platinum on carbon; hydrogen; sodium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1517/13543776.2014.851670