2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate

Base Information

• Chemical Name: 2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate
• CAS No.: 1402012-65-0
• Molecular Formula: C₁₆H₁₁Cl₃O₄
• Molecular Weight: 373.62
• Mol file: 1402012-65-0.mol

Synonyms:2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate

Chemical Property of 2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate

There total 3 articles about 2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Ethyl 4-bromobenzoate (5798-75-4) + (2,4,6-trichlorophenyl) formate (4525-65-9) → 2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate (1402012-65-0)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1248/cpb.c18-00042

Reference yield: 85.0%

4-iodobenzoic acid ethyl ester (51934-41-9) + (2,4,6-trichlorophenyl) formate (4525-65-9) → 2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate (1402012-65-0)

Guidance literature:

With α,α,α-trifluorotoluene; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol302593z

Reference yield:

2,4,6-Trichlorophenol (88-06-2,67471-29-8) → 2,4,6-trichlorophenyl 4-ethoxycarbonylbenzoate (1402012-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride / 1 h / 20 - 60 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; triethylamine; α,α,α-trifluorotoluene / 20 °C / Inert atmosphere

With α,α,α-trifluorotoluene; palladium diacetate; acetic anhydride; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;

DOI:10.1021/ol302593z

upstream raw materials:

2,4,6-Trichlorophenol

4-iodobenzoic acid ethyl ester

(2,4,6-trichlorophenyl) formate

Ethyl 4-bromobenzoate