(+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone

Base Information

• Chemical Name: (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone
• CAS No.: 158558-35-1
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.175
• Mol file: 158558-35-1.mol

Synonyms:(+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone

Chemical Property of (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone

There total 7 articles about (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-bromo-1-(4-trifluoromethylphenyl)propan-1-one (95728-57-7) → (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone (158558-35-1)

Guidance literature:

With lithium hydroxide; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

DOI:10.1021/jm00020a005

Reference yield: 65.0%

(+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol (67081-98-5) → (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone (158558-35-1)

Guidance literature:

(+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol; With iodine; acetone; In 1,4-dioxane; at 20 ℃; for 0.0833333h;

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In 1,4-dioxane; at 80 ℃; for 32h;

DOI:10.1039/c7cc05697d

Reference yield: 61.0%

4-trifluoromethyl propiophenone (711-33-1) → (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone (158558-35-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; iodine; In methanol; at 20 ℃; for 14h; Irradiation;

upstream raw materials:

2-bromo-1-(4-trifluoromethylphenyl)propan-1-one

4-Trifluoromethylbenzaldehyde

4-trifluoromethyl propiophenone

(+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol

Downstream raw materials:

α-(tetrahydropyran-2-yloxy)-4-(trifluoromethyl)propiophenone

(+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Refernces

• 1、 Guha, Somraj,Kazi, Imran,Mukherjee, Pranamita,Sekar, Govindasamy. "Halogen-bonded iodonium ion catalysis: A route to α-hydroxy ketones: Via domino oxidations of secondary alcohols and aliphatic C-H bonds with high selectivity and control". supporting information. p. 10942 - 10945. Retrieved 2017/10/13.
• 2、 Bartroli,Turmo,Alguero,Boncompte,Vericat,Garcia-Rafanell,Forn. "Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring". . p. 3918 - 3932. Retrieved 2007/10/03.