2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

Base Information

Chemical Name:2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate
CAS No.:1132675-14-9
Molecular Formula:C₃₈H₄₂BF₃O₉S
Molecular Weight:742.618
Hs Code.:

2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

Synonyms:2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

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Chemical Property of 2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

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Technology Process of 2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

There total 12 articles about 2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1132675-13-8
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

: 73183-34-3
bis(pinacol)diborane

: 1132675-14-9
2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 4.5h;
DOI:10.1016/j.bmcl.2008.12.022

Reference yield:

: 1448000-67-6
(E)-methyl 3-(4-(2-bromo-5-methoxystyryl)phenoxy)-4-methoxybenzoate

: 1132675-14-9
2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: toluene / 2 h / 0 °C

3.1: benzene / 24 h / 100 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

4.2: 3 h / 0 °C

5.1: trifluoroacetic acid / 2.5 h / 60 °C

6.1: caesium carbonate / acetonitrile; N,N-dimethyl-formamide / 8 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 4 h / 100 °C

With potassium phosphate; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile; benzene; 3.1: |Arbuzov Reaction;
DOI:10.1016/j.tet.2013.06.064

Reference yield:

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 1132675-14-9
2-methoxy-4-(4-methoxy-3-(4-(5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)phenoxy)phenethyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 2 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

4.1: toluene / 2 h / 0 °C

5.1: benzene / 24 h / 100 °C

6.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

6.2: 3 h / 0 °C

7.1: trifluoroacetic acid / 2.5 h / 60 °C

8.1: caesium carbonate / acetonitrile; N,N-dimethyl-formamide / 8 h / 20 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 4 h / 100 °C

With potassium phosphate; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile; benzene; 5.1: |Arbuzov Reaction;
DOI:10.1016/j.tet.2013.06.064