4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate
CAS No.:1132675-13-8
Molecular Formula:C₃₂H₃₀BrF₃O₇S
Molecular Weight:695.551
Hs Code.:

Synonyms:4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

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Chemical Property of 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

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Technology Process of 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

There total 12 articles about 4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1132675-12-7
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenol

: phenylbis[(trifluoromethyl)sulfonyl]amine

: 1132675-13-8
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 8h;
DOI:10.1016/j.tet.2013.06.064

Reference yield: 96.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1132675-12-7
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenol

: 1132675-13-8
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; acetonitrile; for 8.5h;
DOI:10.1016/j.bmcl.2008.12.022

Reference yield:

: 1448000-67-6
(E)-methyl 3-(4-(2-bromo-5-methoxystyryl)phenoxy)-4-methoxybenzoate

: 1132675-13-8
4-(3-(4-(2-bromo-5-methoxyphenethyl)phenoxy)-4-methoxyphenethyl)-2-methoxyphenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: toluene / 2 h / 0 °C

3.1: benzene / 24 h / 100 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

4.2: 3 h / 0 °C

5.1: trifluoroacetic acid / 2.5 h / 60 °C

6.1: caesium carbonate / acetonitrile; N,N-dimethyl-formamide / 8 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile; benzene; 3.1: |Arbuzov Reaction;
DOI:10.1016/j.tet.2013.06.064