S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt

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Chemical Name:S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt
CAS No.:1311291-19-6
Molecular Formula:C₂HF₃O₂*C₂₄H₂₈N₂O₈S
Molecular Weight:618.585
Hs Code.:

Synonyms:S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt

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Chemical Property of S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt

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Technology Process of S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt

There total 8 articles about S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23060-14-2
diethyl 2-mercaptosuccinate

: C₁₆H₁₅ClN₂O₄

: 76-05-1
trifluoroacetic acid

: 1311291-19-6
S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt

Guidance literature:: diethyl 2-mercaptosuccinate; C₁₆H₁₅ClN₂O₄; With pyridine; In dichloromethane; at 20 ℃; for 0.75h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 13529-17-4
5-Formyl-2-furancarboxylic acid

: 1311291-19-6
S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: hexane; acetone / 0.17 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: lithium hydroxide / water; methanol / 1.67 h / 20 °C

3.2: 0.17 h

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 20 °C

5.1: 0.25 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

7.1: thionyl chloride / 0.25 h / 70 °C

8.1: pyridine / dichloromethane / 0.75 h / 20 °C

With pyridine; thionyl chloride; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; water; acetone;

Reference yield:

: 5904-71-2
methyl 5-formylfuran-2-carboxylate

: 1311291-19-6
S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: lithium hydroxide / water; methanol / 1.67 h / 20 °C

2.2: 0.17 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 20 °C

4.1: 0.25 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

6.1: thionyl chloride / 0.25 h / 70 °C

7.1: pyridine / dichloromethane / 0.75 h / 20 °C

With pyridine; thionyl chloride; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;