methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate
CAS No.:929095-37-4
Molecular Formula:C₂₇H₂₉F₃N₂O₅S
Molecular Weight:550.599
Hs Code.:

Synonyms:methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

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Chemical Property of methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

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Technology Process of methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

There total 9 articles about methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 929095-36-3
methyl 5-[(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-nitrophenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

: 929095-37-4
methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

Guidance literature:: With hydrogen; 5 wt% sulfided platinum on carbon; In ethyl acetate; at 20 ℃; for 1h; under 2585.81 Torr;

Reference yield:

: 929095-34-1
3-hydroxy-4-nitrobenzyl pivalate

: 929095-37-4
methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / toluene / 2 h / 100 °C

3: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 1 h / 2585.81 Torr

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; 5 % platinum on sulfided carbon; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In dichloromethane; ethyl acetate; toluene; 2: Suzuki Coupling;

Reference yield:

: 929039-92-9
methyl 5-amino-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

: 929095-37-4
methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / toluene / 2 h / 100 °C

2: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 1 h / 2585.81 Torr

With hydrogen; potassium carbonate; 5 % platinum on sulfided carbon; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In ethyl acetate; toluene; 1: Suzuki Coupling;