ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate
CAS No.:1346608-07-8
Molecular Formula:C₃₀H₂₈ClN₃O₇
Molecular Weight:578.021
Hs Code.:

ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

Synonyms:ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

There total 2 articles about ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.5%

: 167300-06-3
3-(methoxycarbonyl)-4-methylbenzoic acid

: 1272674-58-4
ethyl 3-amino-5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-1H-pyrrole-2-carboxylate

: 1346608-07-8
ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

Guidance literature:: 3-(methoxycarbonyl)-4-methylbenzoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 90 ℃; for 5h;

ethyl 3-amino-5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-1H-pyrrole-2-carboxylate; In toluene; at 50 ℃; for 72h;

Reference yield:

: 259209-17-1
[2-hydroxy-3-(methyloxy)phenyl]boronic acid

: 1346608-07-8
ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 5 h / 90 °C

2.2: 72 h / 50 °C

With diphenyl phosphoryl azide; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; toluene;

Reference yield: 44.6%

: 1346608-07-8
ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate

: 1346607-24-6
5-{6-chloro-5-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-2,4-dioxo-1,2,4,5-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-3-yl}-2-methylbenzoic acid

Guidance literature:: ethyl 5-chloro-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-3-{[({4-methyl-3-[(methyloxy)carbonyl]phenyl}amino)carbonyl]amino}-1H-pyrrole-2-carboxylate; With sodium hydroxide; In ethanol; at 90 ℃;

With hydrogenchloride; In ethanol; water;