4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile

Base Information

• Chemical Name: 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile
• CAS No.: 1383377-51-2
• Molecular Formula: C₁₇H₁₀FN₅
• Molecular Weight: 303.298
• Mol file: 1383377-51-2.mol

Synonyms:4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile

Chemical Property of 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile

There total 7 articles about 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

potassium cyanide + 3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile (1383377-50-1) → 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile (1383377-51-2)

Guidance literature:

In dimethyl sulfoxide; at 50 ℃; for 2h;

DOI:10.1021/acschemneuro.7b00155

Reference yield:

3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1286230-78-1) → 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile (1383377-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 50 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

3-fluoro-4-iodo-2-pyridinecarbonitrile (669066-35-7) → 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-2,3-dicarbonitrile (1383377-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 50 °C

With caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

DOI:10.1021/acschemneuro.7b00155

upstream raw materials:

3-fluoro-4-iodo-2-pyridinecarbonitrile

3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine

3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine 1-oxide

Downstream raw materials:

4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-6-methyl-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-6,7-dihydro-5Hpyrrolo[3,4-b]pyridin-5-one

4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione