H-P-FLUORO-DL-PHE-OME HCL

Base Information

• Chemical Name: H-P-FLUORO-DL-PHE-OME HCL
• CAS No.: 64282-12-8
• Molecular Formula: C10H12 F N O2 . Cl H
• Molecular Weight: 233.67
• Hs Code.: 2922499990
• Mol file: 64282-12-8.mol

Synonyms:Phenylalanine,4-fluoro-, methyl ester, hydrochloride (9CI); 4-Fluorophenylalanine methyl esterhydrochloride; NSC 523088

Chemical Property of H-P-FLUORO-DL-PHE-OME HCL

Chemical Property:

• Melting Point: 176.5-178.5 °C
• PSA: 52.32000
• LogP: 2.37080
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

4-Fluoro-DL-phenylalanine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-P-Fluoro-DL-Phe-OMe HCl

Technology Process of H-P-FLUORO-DL-PHE-OME HCL

There total 2 articles about H-P-FLUORO-DL-PHE-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 4-Fluorophenylalanine (51-65-0) → 4-fluoro-DL-phenylalanine methyl ester hydrochloride (64282-12-8,176896-72-3,24602-11-7)

Guidance literature:

With thionyl chloride; at 20 ℃; for 48h;

DOI:10.1002/jlcr.918

Reference yield:

C23H20FNO2 → 4-fluoro-DL-phenylalanine methyl ester hydrochloride (64282-12-8,176896-72-3,24602-11-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃;

DOI:10.1016/j.bmc.2008.07.080

Reference yield: 69.0%

triphenylpyrylium tetrafluoroborate + 4-fluoro-DL-phenylalanine methyl ester hydrochloride (64282-12-8,176896-72-3,24602-11-7) → 1-(3-(4-fluorophenyl)-1-methoxy-1-oxopropan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

Guidance literature:

triphenylpyrylium tetrafluoroborate; 4-fluoro-DL-phenylalanine methyl ester hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Schlenk technique; Molecular sieve; Sealed tube;

With acetic acid; In dichloromethane; at 20 ℃; for 5h; Schlenk technique; Molecular sieve; Sealed tube;

DOI:10.1021/acs.orglett.0c04287

upstream raw materials:

methanol

4-Fluorophenylalanine

Downstream raw materials:

(R)-4-fluorophenylalanine

L-4-fluorophenylalanine

4-fluoro-(RS)-phenylalaninamide hydrochloride

(R)-4-fluoro-N-benzoyl-phenylalanine methylester

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