3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine

Base Information

Chemical Name:3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine
CAS No.:364619-17-0
Molecular Formula:C₃₆H₄₉NO₆Si₂
Molecular Weight:647.959
Hs Code.:

Synonyms:3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine

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Chemical Property of 3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine

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Technology Process of 3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine

There total 1 articles about 3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 161392-58-1
3,4-bis(tert-butyldimethylsilyloxy)-L-phenylalanine

: 364619-17-0
3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine

Guidance literature:: 3,4-bis(tert-butyldimethylsilyloxy)-L-phenylalanine; With sodium carbonate; In 1,4-dioxane; water; for 0.166667h;

(fluorenylmethoxy)carbonyl chloride; In 1,4-dioxane; water; for 22h;
DOI:10.1016/S0040-4020(01)00601-9

Reference yield: 81.0%

: 35661-39-3,136132-75-7
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 364619-17-0
3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine

: Fmoc-Ala-DOPA(TBDMS)₂-OH

Guidance literature:: 3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1.16667h;

With piperidine; In N,N-dimethyl-formamide; for 0.166667h;

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Further stages;
DOI:10.1016/j.tet.2018.10.021

Reference yield: 79.0%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 109425-51-6
Fmoc-His(Trt)-OH

: 364619-17-0
3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine

: Fmoc-His(Trt)-DOPA(TBDMS)₂-Gly-OH

Guidance literature:: N-(fluoren-9-ylmethoxycarbonyl)glycine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1.16667h;

With piperidine; In N,N-dimethyl-formamide; for 0.5h;

Fmoc-His(Trt)-OH; 3,4-bis(tert-butyldimethylsilyloxy)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine; Further stages;
DOI:10.1039/c7ob01122a