5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

Base Information

Chemical Name:5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide
CAS No.:1563184-70-2
Molecular Formula:C₁₄H₁₉Cl₂N₃O₆S
Molecular Weight:428.293
Hs Code.:

Synonyms:5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

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Chemical Property of 5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

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Technology Process of 5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

There total 7 articles about 5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1563184-54-2
5-(bis(2-hydroxyethyl)amino)-4-(methylsulfonyl)-2-nitrobenzoic acid

: 141-43-5
ethanolamine

: 1563184-70-2
5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

Guidance literature:: 5-(bis(2-hydroxyethyl)amino)-4-(methylsulfonyl)-2-nitrobenzoic acid; With thionyl chloride; N,N-dimethyl-formamide; for 4h; Reflux;

ethanolamine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 185945-90-8
5-fluoro-4-(methylsulfonyl)-2-nitrobenzoic acid

: 1563184-70-2
5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide / 2 h / 45 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

2.2: 0.33 h / 0 °C

With thionyl chloride; N,N-dimethyl-formamide; In dimethyl sulfoxide;

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 1563184-70-2
5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 3 h / 75 °C / Inert atmosphere

2.1: sodium dihydrogen phosphate monohydrate; dihydrogen peroxide; sodium chlorite; hydrogenchloride / acetonitrile; water / 0 - 20 °C

3.1: sulfuric acid; nitric acid / 4 h / 45 °C

4.1: dimethyl sulfoxide / 2 h / 45 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

5.2: 0.33 h / 0 °C

With hydrogenchloride; sodium chlorite; thionyl chloride; sodium dihydrogen phosphate monohydrate; sulfuric acid; dihydrogen peroxide; nitric acid; N,N-dimethyl-formamide; In water; dimethyl sulfoxide; acetonitrile;