(4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

Base Information

Chemical Name:(4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester
CAS No.:130543-46-3
Molecular Formula:C₅₀H₆₀O₇Si
Molecular Weight:801.108
Hs Code.:

Synonyms:(4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

Suppliers and Price of (4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

There total 9 articles about (4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 130543-45-2
(4R,5R,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-hydroxy-2-methylene-octanoic acid benzyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130543-46-3
(4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85595-2

Reference yield:

: 100-39-0
benzyl bromide

: 130543-46-3
(4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaH, n-Bu₄NI / tetrahydrofuran / 15 h / Ambient temperature

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 2) rt, 6 h

3: 44 percent / CrCl₂ / tetrahydrofuran / 1.5 h / Ambient temperature

4: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; chromium dichloride; dimethylsulfide; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85595-2

Reference yield:

: 130543-49-6
(2E,5E)-1,7-Bis-benzyloxy-hepta-2,5-dien-4-ol

: 130543-46-3
(4R,5S,6R,7R)-5,6,7,8-Tetrakis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-methylene-octanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / 1.) D-(-)-diisoprop
2: 90 percent / pyridine / CH₂Cl₂ / Ambient temperature

3: 1.) BF₃*OEt₂, 2.) H₂SO₄ / 1.) ether, -20 deg C, 2 h, 2.) rt, 5 h

4: 97 percent / NaOMe / methanol / 5 h / Ambient temperature

5: 95 percent / NaH, n-Bu₄NI / tetrahydrofuran / 15 h / Ambient temperature

6: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 2) rt, 6 h

7: 44 percent / CrCl₂ / tetrahydrofuran / 1.5 h / Ambient temperature

8: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With pyridine; 1H-imidazole; chromium dichloride; titanium(IV) isopropylate; tert.-butylhydroperoxide; dimethylsulfide; sulfuric acid; boron trifluoride diethyl etherate; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; D-(-)-diisopropyl tartrate; ozone; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85595-2