tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate

Base Information

• Chemical Name: tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate
• CAS No.: 1630758-11-0
• Molecular Formula: C₃₆H₄₄N₂O₈
• Molecular Weight: 632.754
• Mol file: 1630758-11-0.mol

Synonyms:tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate

Chemical Property of tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate

There total 3 articles about tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,4-bis(bromomethyl)-2,3,5,6-tetramethylbenzene (35168-64-0) + diethyl 5-aminoisophthalate (42122-73-6) → tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate (1630758-11-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 10 - 20 ℃; for 17h; Inert atmosphere;

DOI:10.1002/ejic.201402094

Reference yield:

1,2,4,5-tetramethylbenzene (95-93-2) → tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate (1630758-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / water / 12.33 h / 85 - 95 °C

2: potassium carbonate / acetonitrile / 17 h / 10 - 20 °C / Inert atmosphere

With hydrogen bromide; potassium carbonate; acetic acid; In water; acetonitrile;

DOI:10.1002/ejic.201402094

Reference yield:

5-aminoisophthalic acid (99-31-0) → tetraethyl 5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)-bis(azanediyl)diisophthalate (1630758-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 12 h / 100 °C / Reflux

2: potassium carbonate / acetonitrile / 17 h / 10 - 20 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; In acetonitrile;

DOI:10.1002/ejic.201402094

upstream raw materials:

1,4-bis(bromomethyl)-2,3,5,6-tetramethylbenzene

diethyl 5-aminoisophthalate

5-aminoisophthalic acid

1,2,4,5-tetramethylbenzene

Downstream raw materials:

5,5'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene)bis(azanediyl)diisophthalic acid