N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide

Base Information

• Chemical Name: N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide
• CAS No.: 1426227-96-4
• Molecular Formula: Br*C₃₃H₂₇N₂O₅
• Molecular Weight: 611.492
• Mol file: 1426227-96-4.mol

Synonyms:N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide

Chemical Property of N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide

There total 3 articles about N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-bromo-N,N-diphenylacetamide (6335-34-8) + berberrubine (108275-17-8,6847-93-4) → N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide (1426227-96-4)

Guidance literature:

With triethylamine; In acetonitrile; at 100 ℃; for 4.5h;

DOI:10.1007/s10600-013-0461-z

Reference yield:

berberine chloride (633-65-8) → N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide (1426227-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 190 - 200 °C / 20 - 30 Torr

2: triethylamine / acetonitrile / 4.5 h / 100 °C

With triethylamine; In acetonitrile;

DOI:10.1007/s10600-013-0461-z

Reference yield:

diphenylamine (122-39-4) → N,N-diphenyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetamide (1426227-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 3.5 h / -25 - 20 °C

2: triethylamine / acetonitrile / 4.5 h / 100 °C

With triethylamine; In dichloromethane; acetonitrile;

DOI:10.1007/s10600-013-0461-z

upstream raw materials:

2-bromo-N,N-diphenylacetamide

berberrubine

berberine chloride

diphenylamine