methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

Base Information

Chemical Name:methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester
CAS No.:1037235-85-0
Molecular Formula:C₁₉H₂₈ClNO₅S
Molecular Weight:417.954
Hs Code.:

Synonyms:methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

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Chemical Property of methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

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Technology Process of methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

There total 6 articles about methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1037235-83-8
[trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

: 124-63-0
methanesulfonyl chloride

: 1037235-85-0
methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2013.12.118

Reference yield:

: 65619-29-6
1-(3-chlorophenyl)-4-oxocyclohexanecarbonitrile

: 1037235-85-0
methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 4 h / Reflux

1.2: 16 h / 20 °C

2.1: triphenylphosphine; C₈H₁₄N₂O₄ / tetrahydrofuran / 20 h / 20 °C

3.1: sodium methylate / methanol; tetrahydrofuran / 15 h / 20 °C

4.1: triethylamine / dichloromethane / 16 h / 20 °C

With borane-THF; C₈H₁₄N₂O₄; sodium methylate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 2.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.12.118

Reference yield:

: 1037235-79-2
[cis-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

: 1037235-85-0
methanesulphonic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; C₈H₁₄N₂O₄ / tetrahydrofuran / 20 h / 20 °C

2: sodium methylate / methanol; tetrahydrofuran / 15 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 20 °C

With C₈H₁₄N₂O₄; sodium methylate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.12.118