ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate

Base Information

Chemical Name:ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate
CAS No.:1450623-95-6
Molecular Formula:C₃₀H₃₃N₃O₆
Molecular Weight:531.609
Hs Code.:

Synonyms:ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate

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Chemical Property of ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate

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Technology Process of ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate

There total 1 articles about ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 623-73-4
diazoacetic acid ethyl ester

: 537030-19-6
(2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide

: 1450623-95-6
ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.07.044

Reference yield: 97.0%

: 1450623-95-6
ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate

: (2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(ethoxycarbonyl)-2,3,4,5-tetrahydropyridine 1-oxide

Guidance literature:: With silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.333333h; Reagent/catalyst; Solvent; Time; Inert atmosphere;
DOI:10.1021/ol502029z

Reference yield: 96.0%

: 1450623-95-6
ethyl 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-hydroxypyrrolidin-2-yl)-2-diazoacetate

: (2R,3R,4R)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-(2-ethoxy-2-oxoethyl)-3,4-dihydro-2H-pyrrole 1-oxide

Guidance literature:: With silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1002/ejoc.201601255