ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate

Base Information

Chemical Name:ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate
CAS No.:1353743-58-4
Molecular Formula:C₁₇H₂₄N₂O₆
Molecular Weight:352.387
Hs Code.:

Synonyms:ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate

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Chemical Property of ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate

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Technology Process of ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate

There total 2 articles about ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 738535-66-5
ethyl 2-amino-3-hydroxy-3-methylbutanoate

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 1353743-58-4
ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate

Guidance literature:: With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tetlet.2021.153175

Reference yield:

: 638-10-8
ethyl 3-methylbut-2-enoate

: 1353743-58-4
ethyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-hydroxy-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: osmium(VIII) oxide / water; acetonitrile / 0.17 h / 20 °C

1.2: 10 h / 35 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 23 h / 20 °C / 23272.3 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

With osmium(VIII) oxide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo202375a