(S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE

Base Information

• Chemical Name: (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE
• CAS No.: 103300-84-1
• Molecular Formula: C12H12N2O4
• Molecular Weight: 248.238
• Mol file: 103300-84-1.mol

Synonyms:4-Pyrimidinecarboxylicacid, hexahydro-2,6-dioxo-, phenylmethyl ester, (S)- (9CI);

Chemical Property of (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE

Chemical Property:

• PSA: 84.50000
• LogP: 0.98550

Purity/Quality:

99% ^*data from raw suppliers

(S)-Benzyl2,6-dioxohexahydropyrimidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE

There total 1 articles about (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

benzyl bromide (100-39-0) + L-dihydroorotic acid (5988-19-2,6202-10-4) → benzyl (S)-dihydroorotate (103300-84-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1248/cpb.37.1764

Reference yield: 86.0%

benzyl (S)-dihydroorotate (103300-84-1) + methyl iodide (74-88-4) → benzyl 3-methyldihydroorotate (103365-71-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1248/cpb.37.1764

Reference yield: 61.1%

benzyl (S)-dihydroorotate (103300-84-1) + isopropyl alcohol (67-63-0,8013-70-5) → (S)-1-Isopropyl-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid benzyl ester (124798-91-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; for 4h; Heating;

DOI:10.1248/cpb.37.1764

upstream raw materials:

benzyl bromide

L-dihydroorotic acid

Downstream raw materials:

(S)-1-Octadecyl-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid benzyl ester

benzyl (S)-3-ethyldihydroorotate

(S)-2,6-Dioxo-1-pentyl-hexahydro-pyrimidine-4-carboxylic acid benzyl ester

(S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid benzyl ester

Refernces