2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione

Base Information

• Chemical Name: 2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione
• CAS No.: 154084-92-1
• Molecular Formula: C₁₇H₂₆O₂
• Molecular Weight: 262.392
• Mol file: 154084-92-1.mol

Synonyms:2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione

Chemical Property of 2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione

There total 4 articles about 2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,5-Dimethoxy-6-[2-(2,6,6-trimethyl-cyclohex-2-enyl)-ethyl]-cyclohexa-1,4-diene (154084-91-0) → 2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione (154084-92-1)

Guidance literature:

With hydrogenchloride; In acetone; for 4h;

DOI:10.1016/S0040-4020(01)80759-6

Reference yield:

1,5-dimethoxy-1,4-cyclohexadiene (37567-78-5) → 2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione (154084-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / tert-BuLi, HMPA / pentane; tetrahydrofuran / -78 degC, 15 min, allowed to warm to 23 degC, 2 h

2: 63 percent / 1N HCl / acetone / 4 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; In tetrahydrofuran; acetone; pentane;

DOI:10.1016/S0040-4020(01)80759-6

Reference yield:

2-(2,6,6-trimethyl-cyclohex-2-enyl)-ethanol (472-63-9) → 2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-1,3-cyclohexadione (154084-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / Ph₃P, imidazole, iodine / acetonitrile; diethyl ether / 1 h / 0 °C

2: 100 percent / tert-BuLi, HMPA / pentane; tetrahydrofuran / -78 degC, 15 min, allowed to warm to 23 degC, 2 h

3: 63 percent / 1N HCl / acetone / 4 h

With 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; iodine; tert.-butyl lithium; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetone; acetonitrile; pentane;

DOI:10.1016/S0040-4020(01)80759-6

upstream raw materials:

1,5-Dimethoxy-6-[2-(2,6,6-trimethyl-cyclohex-2-enyl)-ethyl]-cyclohexa-1,4-diene

1,5-dimethoxy-1,4-cyclohexadiene

2-(2,6,6-trimethyl-cyclohex-2-enyl)-ethanol

(+/-)-3-(2-Iodoethyl)-2,4,4-trimethyl-1-cyclohexene

Downstream raw materials:

2-(2-(2,6,6-trimethyl-2-cyclohexenyl)ethyl)-3-(trifluoromethansulfonyl)oxy-cyclohexenone

Refernces