(1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol

Base Information

Chemical Name:(1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol
CAS No.:133094-88-9
Molecular Formula:C₁₇H₂₄O₃S₂
Molecular Weight:340.508
Hs Code.:

Synonyms:(1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol

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Chemical Property of (1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol

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Technology Process of (1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol

There total 6 articles about (1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1125-88-8
benzaldehyde dimethyl acetal

: 133094-83-4
(1S,2R)-1,2-syn-3,3-dimethyl-1-(1,3-dithian-2-yl)-1,2,4-butanetriol

: 133094-88-9
(1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 1h; Ambient temperature;
DOI:10.1139/v91-009

Reference yield:

: 599-04-2
(R)-Pantolacton

: 133094-88-9
(1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / BH₃-THF / tetrahydrofuran / 12 h / Ambient temperature

2: 71 percent / 1.) n-BuLi / 1.) THF, hexane, -20 degC, 2a) THF, -20 degC, 2b) -10 degC

3: 87 percent / TsOH / benzene / 1 h / Ambient temperature

With n-butyllithium; borane-THF; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;
DOI:10.1139/v91-009

Reference yield:

: 298181-27-8
(3R)-3-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-1-oxacyclopentan-2-ol

: 133094-88-9
(1S,2R)-1,2-syn-1,4-O-benzylidene-3,3-dimethyl-1-(1,3-dithian-2-yl)-1-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -20 degC, 2 h, 2a) THF, -20 degC, 2 h, 2b) -10 degC, 18 h

2: MeOH, TsOH

3: 87 percent / TsOH / benzene / 1 h / Ambient temperature

With methanol; n-butyllithium; toluene-4-sulfonic acid; In benzene;
DOI:10.1139/v91-009