Technology Process of (-)-(S)-1-p-bromophenyl-1-hexanol
There total 4 articles about (-)-(S)-1-p-bromophenyl-1-hexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-bromophenyl)hexan-1-one;
With
(-)-diisopinocamphenylborane chloride;
In
tetrahydrofuran;
at -25 ℃;
for 7h;
With
2,2'-iminobis[ethanol];
In
diethyl ether;
at 20 ℃;
for 2h;
Further stages.;
DOI:10.1021/ja0125772
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 90 percent / diethyl ether / 1 h / Heating
2.1: 90 percent / Na2Cr2O7*2H2O; H2SO4 / diethyl ether; H2O / 0.33 h / 0 °C
3.1: (-)-(1R)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 7 h / -25 °C
3.2: 85 percent / diethanolamine / diethyl ether / 2 h / 20 °C
With
sodium dichromate; sulfuric acid; (-)-diisopinocamphenylborane chloride;
In
tetrahydrofuran; diethyl ether; water;
1.1: Grignard reaction;
DOI:10.1021/ja0125772
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 90 percent / Na2Cr2O7*2H2O; H2SO4 / diethyl ether; H2O / 0.33 h / 0 °C
2.1: (-)-(1R)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 7 h / -25 °C
2.2: 85 percent / diethanolamine / diethyl ether / 2 h / 20 °C
With
sodium dichromate; sulfuric acid; (-)-diisopinocamphenylborane chloride;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1021/ja0125772