(R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester

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Chemical Name:(R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester
CAS No.:143347-67-5
Molecular Formula:C₁₂H₁₅NO₄
Molecular Weight:237.255
Hs Code.:

Synonyms:(R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester

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Technology Process of (R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester

There total 1 articles about (R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 126983-29-7
(S)-N-methyl-2-hydroxysuccinimide acrylate

: 106-99-0,130983-70-9,29406-96-0,9003-17-2
buta-1,3-diene

: 143347-67-5
(R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 0 ℃;
DOI:10.1021/jo00045a013

Reference yield: 98.0%

: 143347-67-5
(R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester

: 5709-98-8
(R)-cyclohex-3-enecarboxylic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/jo00045a013

Reference yield:

: 143347-67-5
(R)-Cyclohex-3-enecarboxylic acid (S)-1-methyl-2,5-dioxo-pyrrolidin-3-yl ester

: 143347-72-2
tert-Butyl-((1R,2R,4R)-4-ethynyl-2-methoxy-cyclohexyloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / LiOH, H₂O₂ / tetrahydrofuran / 0 °C

2: 1) MCPBA, 2) Et₃N, SiO₂ / 1) CCl₄, 0 to 25 deg C, 2) 70 deg C

3: 90 percent / imidazole / dimethylformamide / 25 °C

4: NaHCO₃ / 25 °C

5: 2,6-di-tert-butylpyridine / CH₂Cl₂ / 25 °C

6: 100 percent / LiAlH₄ / diethyl ether / 0 °C

7: 1) (COCl)2, DMSO, 2) NEt₃ / 2) CH₂Cl₂, -78 deg C

8: 83 percent / NaH / tetrahydrofuran / -78 °C

With 1H-imidazole; lithium hydroxide; lithium aluminium tetrahydride; 2,6-di-tert-butyl-pyridine; oxalyl dichloride; dihydrogen peroxide; silica gel; sodium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00045a013