α-bromophenylacetic acid N,N-diethylamide

Base Information

• Chemical Name: α-bromophenylacetic acid N,N-diethylamide
• CAS No.: 91801-96-6
• Molecular Formula: C₁₂H₁₆BrNO
• Molecular Weight: 270.169
• Mol file: 91801-96-6.mol

Synonyms:α-bromophenylacetic acid N,N-diethylamide

Chemical Property of α-bromophenylacetic acid N,N-diethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-bromophenylacetic acid N,N-diethylamide

There total 2 articles about α-bromophenylacetic acid N,N-diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-bromophenylacetic acid (4870-65-9,31302-84-8) + diethylamine (109-89-7) → α-bromophenylacetic acid N,N-diethylamide (91801-96-6)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 23 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2011.07.065

Reference yield:

bromo(phenyl)acetyl chloride (19078-72-9) + diethylamine (109-89-7) → α-bromophenylacetic acid N,N-diethylamide (91801-96-6)

Guidance literature:

With tetrachloromethane;

DOI:10.1021/ja01178a064

Reference yield: 78.0%

1,2,3-trimethoxybenzene (634-36-6) + α-bromophenylacetic acid N,N-diethylamide (91801-96-6) → N,N-diethyl-2-phenyl-2-(2,4,6-trimethoxyphenyl)acetamide (1332709-02-0)

Guidance literature:

With silver trifluoromethanesulfonate; In dichloromethane; at -78 - 23 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.tet.2011.07.065

upstream raw materials:

bromo(phenyl)acetyl chloride

diethylamine

2-bromophenylacetic acid

Downstream raw materials:

α-(diphenylphosphinyl)phenylacetic acid N,N-diethylamide

2-[4-(4-nitro-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide

biphenyl-2-carboxylic acid (4-[4-(diethylcarbamoyl-phenyl-methyl)-piperazin-1-yl]-3-fluoro-phenyl)-amide

N,N-diethyl-2-[4-(2-fluoro-4-formyl-phenyl)-piperazin-1-yl]-2-phenyl-acetamide