2',5'-DICHLOROPROPIOPHENONE

Base Information

• Chemical Name: 2',5'-DICHLOROPROPIOPHENONE
• CAS No.: 99846-93-2
• Molecular Formula: C9H8Cl2O
• Molecular Weight: 203.07
• Hs Code.: 2914700090
• Mol file: 99846-93-2.mol

Synonyms:2,5-DICHLOROPROPIOPHENONE;1-(2,5-dichlorophenyl)propan-1-one;1-(2,5-Dichlorophenyl)-1-propanone

Chemical Property of 2',5'-DICHLOROPROPIOPHENONE

Chemical Property:

• Boiling Point: 260 °C at 760 mmHg
• Flash Point: 107.2 °C
• PSA: 17.07000
• Density: 1.258g/cm³
• LogP: 3.58610

Purity/Quality:

98% ^*data from raw suppliers

1-(2,5-dichlorophenyl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',5'-DICHLOROPROPIOPHENONE

There total 3 articles about 2',5'-DICHLOROPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dichloro-N-methyl-N-(methyloxy)benzamide + ethylmagnesium bromide (925-90-6) → 1-(2,5-dichlorophenyl)-1-propanone (99846-93-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2015.07.068

Reference yield:

2,5-dichlorobenzoic acid (50-79-3) → 1-(2,5-dichlorophenyl)-1-propanone (99846-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 20 °C

2: tetrahydrofuran; diethyl ether / 3 h / 0 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.bmc.2015.07.068

Reference yield:

para-dichlorobenzene (106-46-7,84348-21-0) + propionyl chloride (79-03-8) → 1-(2,5-dichlorophenyl)-1-propanone (99846-93-2)

Guidance literature:

With aluminium trichloride;

upstream raw materials:

para-dichlorobenzene

propionyl chloride

2,5-dichlorobenzoic acid

ethylmagnesium bromide

Downstream raw materials:

3-(2,5-dichlorophenyl)propanoic acid

1-(2,5-Dichlorphenyl)-propin

Refernces