(S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine

Base Information Edit

Chemical Name:(S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine
CAS No.:1190207-25-0
Molecular Formula:C₂₄H₃₂NO₂P
Molecular Weight:397.497
Hs Code.:
Mol file:1190207-25-0.mol

Synonyms:(S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine

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Chemical Property of (S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine Edit

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Technology Process of (S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine

There total 2 articles about (S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 36042-94-1
bis(o-tolyl)chlorophosphine

: 86661-32-7
(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate

: 1190207-25-0
(S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine

Guidance literature:: bis(o-tolyl)chlorophosphine; With sodium; In 1,4-dioxane; for 6h; Reflux;

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/ol901866y

Reference yield: 83.0%

: 36042-94-1
bis(o-tolyl)chlorophosphine

: 128542-75-6
(S)-2-(bromomethyl)-1-<(tert-butyloxy)carbonyl>pyrrolidine

: 1190207-25-0
(S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine

Guidance literature:: bis(o-tolyl)chlorophosphine; With sodium; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;

(S)-2-(bromomethyl)-1-<(tert-butyloxy)carbonyl>pyrrolidine; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201104105

Reference yield: 99.0%

: 1190207-25-0
(S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: benzyl N-{1-(R)-[(2-(S)-bis(2-methylphenyl)phosphinomethyl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate

Guidance literature:: (S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine; With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; Inert atmosphere;

(S)-N-(benzyloxycarbonyl)valine; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at -20 - 20 ℃; for 19.5h;
DOI:10.1021/ol901866y